CBD can alter the effects of other drugs. Altering the concentration, in turn, may cause the drug to not work or increase the risk of side effects. These drug interactions are often difficult to predict, but they can cause unpleasant and sometimes serious problems. We mentioned earlier that NSAIDs interact with CBD, which may raise concerns about possible negative interactions between CBD oil and ibuprofen.
In addition to more traditional ways of consuming cannabis, such as smoking, there is growing interest in CBD oil, which only contains CBD and not the psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC). This inhibitory effect on CYP450 enzymes depends mainly on the amount of CBD a person takes, their specific physiology and the type of CBD they use (for example, research on CBD oil for migraines is limited, but some evidence suggests that it may help alleviate chronic or acute pain). However, CBD inhibits CYP3A4, which means that taking CBD and sertraline at the same time could be dangerous. Considering that CBD has so many potential health benefits, you may start to wonder if it can interact with certain medications that are used to treat the same symptoms and whether or not you should take these medications with CBD.
If you take any of the substances listed below, be sure to consult your doctor before buying CBD oil. However, more research is needed to determine the severity of CBD interactions between different medications and to develop recommendations for taking them together with CBD.
