CBD has become increasingly popular in recent years, with many people claiming that it helps them feel calmer, more relaxed and less stressed. This is likely due to the fact that CBD activates 5-HT1 receptors, which have a direct impact on fear and learned phobias, making it an effective treatment for anxiety disorders such as post-traumatic stress disorder (PTSD). In addition to reducing anxiety and depression, CBD can also help increase energy levels by increasing blood flow throughout the body. Research suggests that CBD may also be beneficial in treating a variety of other conditions.
For example, a large scale study on the use of CBD in the treatment of pediatric epilepsy found that it reduced the frequency of seizures by more than 50% in 43% of patients with Dravet syndrome. However, further research is needed to determine the full range of potential benefits and effects of CBD. It is also possible that CBD could be affecting endocannabinoid signaling through NAPE-PLD, although this hypothesis is purely speculative. A recent comprehensive review of research suggests that support for the uses of CBD for mental health remains inadequate.
Therefore, it would be interesting to study the effects of chronic doses of CBD to determine if steady-state concentrations produce detectable behavioral effects.