In addition, CBD may interact with naproxen, tramadol, celecoxib, etoricoxib, fluoxetine and tofacitinib, since they are metabolized in the liver by cytochrome P450 enzymes. Because the consumption of CBD can interfere with the function of CYP enzymes, mixing CBD and PPIs could lead to an increase in the side effects of PPIs. However, more research is needed to determine the severity of CBD interactions between different medications and to develop recommendations for taking them together with CBD. Certain antiepileptic drugs, such as carbamazepine, oxcarbazepine, phenobarbital and phenytoin, can affect CBD metabolism and cause a decrease in CBD levels.
While CBD may be useful for some patients, more research is needed to evaluate the safety and effectiveness of CBD. As the potential uses of CBD continue to expand, more people are becoming interested in over-the-counter CBD products. The side effects of CBD and antidepressants can also overlap, as CBD and antidepressants are associated with side effects on the central nervous system (CNS), such as sleepiness and sleep disturbances. Taking CBD with certain antimicrobials can cause increased levels of CBD in the blood, which can lead to negative side effects of CBD.
CBD isolates mean that only CBD (and possibly other ingredients other than cannabis or hemp) interact with the drug.
